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Complex changes in ecto-nucleoside 5'-triphosphate diphosphohydrolase expression in hypoxanthine phosphoribosyl transferase deficiency

Lorenz, Veronika, Pinto, Cibele S. and Seifert, Roland (2007) Complex changes in ecto-nucleoside 5'-triphosphate diphosphohydrolase expression in hypoxanthine phosphoribosyl transferase deficiency. Neuroscience Letters 420 (1), pp. 6-11.

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Abstract

Lesch-Nyhan disease is caused by a deficiency of the purine salvage enzyme, hypoxanthine phosphoribosyl transferase (HPRT). The link between HPRT deficiency and the neuropsychiatric symptoms is unknown. In rat B103 neuroblastoma cell membranes and mouse Neuro2a neuroblastoma cell membranes, nucleoside 5'-triphosphatase (NTPase) activity is substantially reduced, whereas in fibroblast membranes ...

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Item type:Article
Date:June 2007
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Identification Number:
ValueType
10.1016/j.neulet.2007.04.004DOI
Keywords:Lesch-Nyhan disease; Hypoxanthine phosphoribosyl transferase; Ecto-nucleoside 5′-triphosphate diphosphohydrolase; Fibroblasts; Neuroblastoma cells
Dewey Decimal Classification:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:2669
Owner only: item control page

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