Bacillus anthracis edema factor substrate specificity: evidence for new modes of action

URN to cite this document:: urn:nbn:de:bvb:355-epub-267166
DOI to cite this document:: 10.5283/epub.26716

Göttle, Martin ; Dove, Stefan ; Seifert, Roland

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Date of publication of this fulltext: 15 Nov 2012 09:41

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Abstract

Since the isolation of Bacillus anthracis exotoxins in the 1960s, the detrimental activity of edema factor (EF) was considered as adenylyl cyclase activity only. Yet the catalytic site of EF was recently shown to accomplish cyclization of cytidine 5'-triphosphate, uridine 5'-triphosphate and inosine 5'-triphosphate, in addition to adenosine 5'-triphosphate. This review discusses the broad EF ...