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Towards selective inhibitors of adenylyl cyclase toxin from Bordetella pertussis

Seifert, Roland ; Dove, Stefan



Abstract

Whooping cough is a very important medical problem that requires novel approaches for treatment. The disease is caused by Bordetella pertussis, with the calmodulin (CaM)-activated adenylyl cyclase (AC) toxin (also known as CyaA) being a major virulence factor. Hence, CyaA inhibitors could constitute novel therapeutics, but it has been difficult to develop potent drugs with high selectivity over ...

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