The levels of clarithromycin and its 14-hydroxy metabolite in the lung

URN to cite this document:: urn:nbn:de:bvb:355-epub-268227
DOI to cite this document:: 10.5283/epub.26822

Honeybourne, D. ; Kees, Frieder K. ; Andrews, J. M. ; Baldwin, D. ; Wise, R.

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Date of publication of this fulltext: 29 Nov 2012 06:22

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Abstract

Clarithromycin is a new macrolide that has a longer half-life than erythromycin and is claimed to reach higher tissue concentrations. We aimed to investigate whether, following oral administration, the drug and its 14-hydroxy metabolite reach levels in lung tissue that are likely to be clinically effective against common respiratory pathogens. Ten patients undergoing diagnostic bronchoscopy ...