The concentrations of clarithromycin and its 14-hydroxy metabolite in sputum of patients with bronchiectasis following single dose oral administration

URN to cite this document:: urn:nbn:de:bvb:355-epub-268232
DOI to cite this document:: 10.5283/epub.26823

Tsang, K. W. ; Roberts, P. ; Read, R. C. ; Kees, Frieder ; Wilson, R. ; Cole, P. J.

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Date of publication of this fulltext: 30 Nov 2012 10:47

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Abstract

Clarithromycin and its metabolite, 14-hydroxy-clarithromycin are active against a wide range of respiratory pathogens. Antibiotics generally penetrate poorly into respiratory secretions which may therefore continue to harbour bacteria following bronchial infection. We have studied sputum and serum concentrations of clarithromycin and 14-hydroxy-clarithromycin in eight patients with idiopathic ...