Clarithromycin, ein neues Makrolid-Antibiotikum. Wirksamkeit bei puerperalen Infektionen und Übertritt in die Muttermilch [Clarithromycin, a new macrolide antibiotic. Effectiveness in puerperal infections and pharmacokinetics in breast milk]

URN to cite this document:

urn:nbn:de:bvb:355-epub-268244 Copy

DOI to cite this document:

10.5283/epub.26824 Copy

Sedlmayr, T. ; Petersen, F. ; Raasch, W. ; Kees, Frieder K.

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Date of publication of this fulltext: 29 Nov 2012 12:48

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Details

Item type:	Article
Journal or Publication Title:	Geburtshilfe und Frauenheilkunde
Publisher:	Thieme
Volume:	53
Number of Issue or Book Chapter:	7
Page Range:	pp. 488-491
Date:	1993
Institutions:	Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Identification Number:	Value Type 8370491 PubMed ID 10.1055/s-2007-1022919 DOI
Classification:	Notation Type Administration, Oral MESH Adult MESH Clarithromycin/pharmacokinetics MESH Endometritis/drug therapy MESH Episiotomy MESH Female MESH Humans MESH Milk, Human/metabolism MESH Puerperal Infection/drug therapy MESH Pyelonephritis/drug therapy MESH Surgical Wound Infection/drug therapy MESH
Dewey Decimal Classification:	600 Technology > 615 Pharmacy
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Unknown
Item ID:	26824

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Abstract

The aims of this study were, to determine the pharmacokinetic parameters of clarithromycin and to study the passage of the drug into breast milk. Twelve patients (age 24 to 38; weight 44 to 83 kg), suffering from puerperal infections, were treated orally with 250 mg clarithromycin b.i.d. for 6 days. Samples of blood and breast milk were taken at timed intervals. The specimens were assayed for ...

Abstract

The aims of this study were, to determine the pharmacokinetic parameters of clarithromycin and to study the passage of the drug into breast milk. Twelve patients (age 24 to 38; weight 44 to 83 kg), suffering from puerperal infections, were treated orally with 250 mg clarithromycin b.i.d. for 6 days. Samples of blood and breast milk were taken at timed intervals. The specimens were assayed for clarithromycin and its active metabolite 14-hydroxy-clarithromycin by HPLC and electrochemical detection. Serum concentrations of clarithromycin in the investigated patients were higher than those reported in healthy volunteers. The mean peak concentrations of clarithromycin and 14-hydroxy-clarithromycin in breast milk were about 25%, and 75% respectively of the corresponding serum concentrations. All patients recovered within 2 to 4 days and no drug-associated side effects (eg. gastrointestinal) were noted. Clarithromycin appears to be an appropriate antibiotic for the treatment of puerperal infections and (because of its considerable concentrations in breast milk) for puerperal mastitis as well.

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