Cardiovascular parameters and catecholamines in volunteers during passive orthostasis. Influence of antihypotensive drugs

URN to cite this document:

urn:nbn:de:bvb:355-epub-268260 Copy

DOI to cite this document:

10.5283/epub.26826 Copy

Dominiak, P. ; Kees, Frieder K. ; Welzel, D. ; Grobecker, H.

Preview

PDF (1MB)

Date of publication of this fulltext: 29 Nov 2012 12:46

---

Alternative links to fulltext:Pubmed

---

Details

Item type:	Article
Journal or Publication Title:	Arzneimittel-Forschung
Publisher:	Editio-Cantor-Verl./Thieme
Volume:	42
Number of Issue or Book Chapter:	5
Page Range:	pp. 637-642
Date:	1992
Institutions:	Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Identification Number:	Value Type 1530677 PubMed ID
Classification:	Notation Type Adult MESH Blood Pressure/drug effects MESH Cardiovascular Agents/pharmacology MESH Catecholamines/blood MESH Double-Blind Method MESH Electrocardiography/drug effects MESH Female MESH Heart Rate/drug effects MESH Hemodynamics/drug effects MESH Humans MESH Hypotension, Orthostatic/physiopathology MESH Male MESH Stroke Volume/drug effects MESH
Dewey Decimal Classification:	600 Technology > 615 Pharmacy
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Unknown
Item ID:	26826

Preview

Export bibliographical data

ASCII CitationAtomBibTeXData Cite XMLDataCite XML OAIDublin CoreEndNoteHTML CitationJSON LDMETSMODSOpenAPCRDF+N-TriplesRDF+N3RDF+XMLReferReference ManagerSimple MetadataXMLxMetaDissPlus

---

Abstract

To evaluate the therapeutic value of various antihypotensive agents we investigated amezinium (AMZ; CAS 30578-37-1), dihydroergotamine (DHE; CAS 511-12-6), midodrine (MDD; CAS 42794-76-3), and oxilofrine (OXF; CAS 365-26-4) in volunteers during passive orthostasis in a randomized double-blind study against placebo (PCB). Blood pressure, heart rate, and circulating catecholamines were determined ...

Abstract

To evaluate the therapeutic value of various antihypotensive agents we investigated amezinium (AMZ; CAS 30578-37-1), dihydroergotamine (DHE; CAS 511-12-6), midodrine (MDD; CAS 42794-76-3), and oxilofrine (OXF; CAS 365-26-4) in volunteers during passive orthostasis in a randomized double-blind study against placebo (PCB). Blood pressure, heart rate, and circulating catecholamines were determined before and after i.v. injections of the mentioned agents before and during 10 min of passive orthostasis. Echocardiographic and venous plethysmographic data were obtained during resting before and after the administration of the drugs. Resting heart rate decreased after injection of PCB, AMZ, DHE, and MDD. During tilting no significant changes in heart rate could be observed. Blood pressure remained unchanged at rest and during orthostasis after all agents injected. DHE and MDD lowered circulating noradrenaline. Echocardiographic parameters were changed after administration of AMZ (increase in stroke volume index (SVI) and ejection fraction (EF)), MDD (increase in enddiastolic volume index and SVI), and OXF (increase in SVI, EF, and cardiac index). The venous capacity of the lower left leg was only significantly decreased after injection of DHE, indicating an increased venous tone of the leg veins. The observed changes in sympathetic and cardiovascular parameters are in agreement with their sympathomimetic actions and allow a differential therapeutic classification: DHE and MDD are suitable agents for patients with sympathotonic orthostatic reaction; if asympathotonic orthostatic reaction occurs MDD, AMX and OXF should be recommended to those patients.

---

---

Metadata last modified: 26 Nov 2020 03:42

Owner only: item control page

Download Statistics

Download Statistics

Download Statistics

Download Statistics

Downloads

Downloads per month over past year

Altmetric

Altmetric

Altmetric

Alternative Statistics (altmetrics)

More literature (via CORE)

More literature (via CORE)

More literature (via CORE)

More literature (via CORE)