In-vitro activity of fleroxacin against isolates causing complicated urinary tract infections and concentrations in seminal and prostatic fluid and in prostatic adenoma tissue

URN to cite this document:: urn:nbn:de:bvb:355-epub-268414
DOI to cite this document:: 10.5283/epub.26841

Naber, K. G. ; Sörgel, F. ; Kees, Frieder K. ; Schumacher, H. ; Metz, R. ; Grobecker, H.

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Date of publication of this fulltext: 30 Nov 2012 10:30

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Abstract

Fleroxacin is a new fluoroquinolone with a broad antibacterial spectrum and a serum half-life of about 8-12 h. Eighty percent of 400 isolates from complicated or hospital-acquired urinary tract infections were inhibited by a concentration of 1 mg/l and 95% by 4 mg/l. As with other quinolones, fleroxacin is less active in acid urine (pH 5.4) than in Mueller-Hinton broth (pH 7.4). In 12 healthy ...