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The pharmacokinetic properties of cefotetan and its relevance for prophylaxis in elective colorectal surgery

Kujath, P. ; Düsel, W. ; Bruch, H. P. ; Kees, Frieder K.



Abstract

In an open, prospective, non-randomised study involving 112 patients undergoing elective colorectal surgery, the effect of perioperative prophylaxis with cefotetan was investigated. Cefotetan (2g) was administered, pre- and intra-operatively only. Preoperative bowel preparation was done by the standardised "Würzburg Method" i.e. oral metronidazole pre and post orthograde lavage. Mucosal biopsies ...

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