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Comparative clinical and pharmacokinetic aspects of cefotetan versus cefoxitin plus metronidazole in vaginal hysterectomy

Engel, K. J., Schmidt, W., Sonntag, H. G. and Kees, Frieder K. (1988) Comparative clinical and pharmacokinetic aspects of cefotetan versus cefoxitin plus metronidazole in vaginal hysterectomy. Chemioterapia 7 (4), pp. 256-260.

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Abstract

In a randomised clinical trial, 102 women who underwent vaginal hysterectomy were given a single preoperative 2g dose of cefotetan (CTT) (52 pts) or three perioperative 2g doses of cefoxitin (CFX) plus 0.5g metronidazole (50 pts) as antibiotic prophylaxis. No statistically significant differences between the groups were detected in the clinical response (100% for both groups). The incidence of ...

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Item type:Article
Date:1988
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Identification Number:
ValueType
3052894PubMed ID
Classification:
NotationType
AdultMESH
AgedMESH
Bacteria, Aerobic/isolation & purificationMESH
Bacteria, Anaerobic/isolation & purificationMESH
Bacterial Infections/prevention & controlMESH
Cefotetan/therapeutic useMESH
Cefoxitin/pharmacokineticsMESH
Clinical Trials as TopicMESH
Drug Therapy, Combination/therapeutic useMESH
FemaleMESH
HumansMESH
HysterectomyMESH
Hysterectomy, VaginalMESH
Metronidazole/administration & dosageMESH
Middle AgedMESH
Postoperative Complications/prevention & controlMESH
PremedicationMESH
Random AllocationMESH
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Item ID:26843
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