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Penetration of fleroxacin into prostatic secretion and prostatic adenoma tissue

Kees, Frieder K. ; Naber, K. G. ; Schumacher, H. ; Grobecker, H.


In 12 elderly patients, plasma, prostatic secretion and adenoma tissue concentrations of fleroxacin were determined 1-4 h following oral administration of 400 mg. The plasma concentrations ranged between 0.4 and 5.5 micrograms/ml (median 3.7 micrograms/ml), the mean tissue concentrations were slightly higher. The concentrations in prostatic secretion were about one third of the simultaneous ...


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