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Pharmacokinetics, in-vitro activity, therapeutic efficacy and clinical safety of aztreonam vs. cefotaxime in the treatment of complicated urinary tract infections

URN to cite this document:
Naber, K. G. ; Dette, G. A. ; Kees, Frieder K. ; Knothe, H. ; Grobecker, H.
Date of publication of this fulltext: 30 Nov 2012 10:25


The minimal inhibitory concentrations (MICs) of aztreonam and cefotaxime were determined against 400 isolates from urological in-patients with complicated and/or hospital acquired urinary tract infections (UTI). Against the Gram-negative rods the activities of both antibiotics were comparable except for higher activity of aztreonam against Pseudomonas aeruginosa. The pharmacokinetic study in nine ...


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