High-performance liquid chromatography analysis of mezlocillin, piperacillin, their degradation products, and of ioxitalamic acid in plasma and urine of healthy volunteers

URN to cite this document:: urn:nbn:de:bvb:355-epub-268539
DOI to cite this document:: 10.5283/epub.26853

Kees, Frieder K. ; Naber, K. G. ; Bartoschik-Wich, B. ; Stockmann, P. ; Meyer, G. P. ; Grobecker, H.

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Date of publication of this fulltext: 29 Nov 2012 12:35

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Abstract

In plasma and urine of 10 healthy volunteers after intravenous administration of 4 g mezlocillin and piperacillin, respectively, the parent compounds as well as degradation products were assayed by high-performance liquid chromatography. Ioxitalamic acid, a renal contrast medium, was administered simultaneously, in order to measure the glomerular filtration rate, and to control the collection of ...