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High-performance liquid chromatography analysis of mezlocillin, piperacillin, their degradation products, and of ioxitalamic acid in plasma and urine of healthy volunteers

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Kees, Frieder K. ; Naber, K. G. ; Bartoschik-Wich, B. ; Stockmann, P. ; Meyer, G. P. ; Grobecker, H.
Date of publication of this fulltext: 29 Nov 2012 12:35


In plasma and urine of 10 healthy volunteers after intravenous administration of 4 g mezlocillin and piperacillin, respectively, the parent compounds as well as degradation products were assayed by high-performance liquid chromatography. Ioxitalamic acid, a renal contrast medium, was administered simultaneously, in order to measure the glomerular filtration rate, and to control the collection of ...


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