High-performance liquid chromatographic analysis of cefotetan epimers in human plasma and urine

URN to cite this document:: urn:nbn:de:bvb:355-epub-268553
DOI to cite this document:: 10.5283/epub.26855

Kees, Frieder K. ; Grobecker, H. ; Naber, K. G.

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Date of publication of this fulltext: 29 Nov 2012 12:22

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Abstract

Cefotetan, a new broad-spectrum 7 alpha-methoxycephalosporin antibiotic, was assayed in plasma and urine by means of reversed-phase high-performance liquid chromatography. Commercially available cefotetan exists in two epimeric forms. The procedure described allows the separation and quantitation of both epimers. For the first time a different pharmacokinetic behaviour (t1/2 = 3 h versus 4 h) for ...