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High-performance liquid chromatographic analysis of cefotetan epimers in human plasma and urine

Kees, Frieder K., Grobecker, H. and Naber, K. G. (1984) High-performance liquid chromatographic analysis of cefotetan epimers in human plasma and urine. Journal of Chromatography B 305 (2), pp. 363-371.

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Abstract

Cefotetan, a new broad-spectrum 7 alpha-methoxycephalosporin antibiotic, was assayed in plasma and urine by means of reversed-phase high-performance liquid chromatography. Commercially available cefotetan exists in two epimeric forms. The procedure described allows the separation and quantitation of both epimers. For the first time a different pharmacokinetic behaviour (t1/2 = 3 h versus 4 h) for ...

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Item type:Article
Date:1984
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Identification Number:
ValueType
6584433PubMed ID
10.1016/S0378-4347(00)83350-2DOI
Classification:
NotationType
Biological AssayMESH
CefotetanMESH
Cephamycins/urineMESH
Chromatography, High Pressure Liquid/methodsMESH
HumansMESH
Indicators and ReagentsMESH
Iothalamic Acid/analysisMESH
Specimen HandlingMESH
StereoisomerismMESH
Time FactorsMESH
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:26855
Owner only: item control page

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