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Comparative determination of cefotaxime and desacetyl cefotaxime in serum and bile by bioassay and high-performance liquid chromatography

Kees, Frieder K., Strehl, E., Seeger, K., Seidel, G., Dominiak, P. and Grobecker, H. (1981) Comparative determination of cefotaxime and desacetyl cefotaxime in serum and bile by bioassay and high-performance liquid chromatography. Arzneimittel-Forschung 31 (2), pp. 362-365.

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Date of publication of this fulltext: 29 Nov 2012 12:33

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Abstract

In rat serum as well as in human serum and bile after injection of cefotaxime (CTX), the parent compound and the active metabolite desacetyl cefotaxime (dCTX) have been demonstrated by quantitative analysis with high-performance liquid chromatography (HPLC). Simultaneous determination of CTX by bioassay using test organisms sensitive to both CTX and dCTX resulted in spuriously high concentration ...

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Item type:Article
Date:1981
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Identification Number:
ValueType
6261772PubMed ID
Classification:
NotationType
AdultMESH
AnimalsMESH
Bile/analysisMESH
Biological Assay/methodsMESH
CefotaximeMESH
Cephalosporins/bloodMESH
Chromatography, High Pressure Liquid/methodsMESH
HumansMESH
MaleMESH
Microbial Sensitivity TestsMESH
RatsMESH
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:26860
Owner only: item control page

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