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Nanofibres Resulating from Cooperative Electrostatic and Hydrophobic Interactions between Peptides and Polyelectrolytes of Opposite Charge

Ferstl, Matthias ; Strasser, Andrea ; Wittmann, Hans-Joachim ; Drechsler, Markus ; Rischer, M. ; Engl, J. ; Goepferich, Achim



Abstract

We investigated whether cationic peptides that contain hydrophobic side chains were able to stabilize themselves via hydrophobic interactions between neighboring peptide molecules upon electrostatic binding to oppositely charged polyelectrolytes. The interaction mechanism was examined through a model system consisting of the anionic polyelectrolyte alginate and the cationic decapeptide ozarelix. ...

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