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Analytical approaches to the study of hyaluronan and hyaluronidases: Development and application of hyphenated chromatographic and electrophoretic methods

URN to cite this document:
urn:nbn:de:bvb:355-epub-279496
Rothenhöfer, Martin
Date of publication of this fulltext: 10 Mar 2014 17:36


Abstract (English)

Hyaluronan (HA) and HA oligosaccharides, which are produced when HA is enzymatically degraded by hyaluronidases, are supposed to have various size-dependent biological effects. To study the (patho)physiological role of HA oligosaccharides, appropriate (bio)analytical methods are a prerequisite. Hence, hyphenated chromatographic and electrophoretic techniques were developed and optimized. ...

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Translation of the abstract (German)

Hyaluronsäure (HA) und HA-Oligosaccharide aus dem enzymatischen Abbau der HA durch Hyaluronidasen besitzen möglicherweise diverse größenabhängige biologische Wirkungen. Um die (patho)physiologische Bedeutung der HA-Oligosaccharide zu untersuchen, sind (bio)analytische Methoden eine Grundvoraussetzung. Daher wurden „gekoppelte“ chromatographische und elektrophoretische Verfahren entwickelt und ...

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