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Suppression of kidney fibrosis by cGMP-dependent protein Kinase Ia

Schinner, E. ; Schramm, A. ; Kees, F. ; Hofmann, F. ; Schlossmann, Jens



Abstract

Cyclic guanosine monophosphate (cGMP) is synthesized by nitric oxide or natriuretic peptide–stimulated guanylyl cyclases and exhibits pleiotropic regulatory functions in the kidney. Hence, integration of cGMP signaling by cGMP-dependent protein kinases (cGKs) might play a critical role in renal physiology; however, detailed renal localization of cGKs is still lacking. Here, we performed an ...

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