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Suppression of kidney fibrosis by cGMP-dependent protein Kinase Ia

Schinner, E. ; Schramm, A. ; Kees, F. ; Hofmann, F. ; Schlossmann, Jens


Cyclic guanosine monophosphate (cGMP) is synthesized by nitric oxide or natriuretic peptide–stimulated guanylyl cyclases and exhibits pleiotropic regulatory functions in the kidney. Hence, integration of cGMP signaling by cGMP-dependent protein kinases (cGKs) might play a critical role in renal physiology; however, detailed renal localization of cGKs is still lacking. Here, we performed an ...


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