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Etablierung von enzymatischer Aktivität auf künstlich erzeugten (βα)8-Barrel Proteinen

Sperl, Josef (2013) Etablierung von enzymatischer Aktivität auf künstlich erzeugten (βα)8-Barrel Proteinen. PhD, Universität Regensburg.

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Date of publication of this fulltext: 25 Jul 2013 14:00

Abstract (German)

Die Grundlage dieser Arbeit bildete das artifizielle (βα)8-Barrel-Protein Sym2. Sym2 ist ein thermostabiles Protein und entstand im Rahmen einer experimentellen Rekonstruktion der (βα)8-Barrel-Evolution im Labor. Dieser lag die Hypothese zugrunde, dass heutige (βα)8-Barrel Enzyme aus einem gemeinsamen Vorfahren halber Länge – dem (βα)4-Halbbarrel – durch Duplikation, Fusion und Diversifikation ...

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Translation of the abstract (English)

This thesis focused on the artificial (βα)8-barrel protein Sym2. Sym2 is a thermostable protein with two-fold symmetry. It was generated during the laboratory reconstruction of (βα)8-barrel evolution which was based on the hypothesis that contemporary (βα)8-barrel enzymes arouse via duplication, fusion and diversification from a common (βα)4-halfbarrel ancestor. In order to mimic this process in ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:25 July 2013
Referee:Prof. Dr. Reinhard Sterner
Date of exam:19 July 2013
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Reinhard Sterner
Keywords:(βα)8-Barrel, Enzymevolution, Proteindesign, Phosphoribosylanthranilat-Isomerase, Imidazolglycerinphosphat-Synthase, Hybridkatalysator enzyme evolution, protein design, phosphoribosylanthranilate isomerase, imidazole glycerol phosphate synthase, hybrid catalyst
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:28576
Owner only: item control page

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