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Ligand-specific contribution of the N-terminus and E2-loop to pharmacological properties of the histamine H1-receptor

Strasser, Andrea ; Wittmann, Hans-Joachim ; Seifert, Roland



Abstract

There are species differences between human histamine H(1) receptor (hH(1)R) and guinea pig (gp) histamine H(1) receptor (gpH(1)R) for phenylhistamines and histaprodifens. Several studies showed participation of the second extracellular loop (E2-loop) in ligand binding for some G protein-coupled receptors (GPCRs). Because there are large species differences in the amino acid sequence between ...

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