Lactate-Modulated Induction of THBS-1 Activates Transforming Growth Factor (TGF)-beta2 and Migration of Glioma Cells In Vitro

URN to cite this document:: urn:nbn:de:bvb:355-epub-291032
DOI to cite this document:: 10.5283/epub.29103

Seliger, Corinna ; Leukel, Petra ; Moeckel, Sylvia ; Jachnik, Birgit ; Lottaz, Claudio ; Kreutz, Marina ; Brawanski, Alexander ; Proescholdt, Martin ; Bogdahn, Ulrich ; Bosserhoff, Anja-Katrin

; Vollmann-Zwerenz, Arabel ; Hau, Peter

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Date of publication of this fulltext: 06 Dec 2013 08:28

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Abstract

Background: An important phenomenon observed in glioma metabolism is increased aerobic glycolysis in tumor cells, which is generally referred to as the Warburg effect. Transforming growth factor (TGF)-beta2, which we previously showed to be induced by lactic acid, is a key pathophysiological factor in glioblastoma, leading to increased invasion and severe local immunosuppression after proteolytic ...