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Lactate-Modulated Induction of THBS-1 Activates Transforming Growth Factor (TGF)-beta2 and Migration of Glioma Cells In Vitro

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Seliger, Corinna ; Leukel, Petra ; Moeckel, Sylvia ; Jachnik, Birgit ; Lottaz, Claudio ; Kreutz, Marina ; Brawanski, Alexander ; Proescholdt, Martin ; Bogdahn, Ulrich ; Bosserhoff, Anja-Katrin ; Vollmann-Zwerenz, Arabel ; Hau, Peter
Date of publication of this fulltext: 06 Dec 2013 08:28


We define a regulatory cascade between lactate, THBS-1 and TGF-beta2, leading to enhanced migration of glioma cells. Our results demonstrate a specific interaction between tumor metabolism and migration and provide a better understanding of the mechanisms underlying glioma cell invasion.

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