| License: Creative Commons: Attribution 3.0 (1MB) |
- URN to cite this document:
- urn:nbn:de:bvb:355-epub-291032
- DOI to cite this document:
- 10.5283/epub.29103
Abstract
Background: An important phenomenon observed in glioma metabolism is increased aerobic glycolysis in tumor cells, which is generally referred to as the Warburg effect. Transforming growth factor (TGF)-beta2, which we previously showed to be induced by lactic acid, is a key pathophysiological factor in glioblastoma, leading to increased invasion and severe local immunosuppression after proteolytic ...

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