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The cancer stem cell subtype determines immune infiltration of glioblastoma

Beier, Christoph P., Kumar, Praveen, Meyer, Katharina, Leukel, Petra, Bruttel, Valentin, Aschenbrenner, Ines, Riemenschneider, Markus J., Fragoulis, Athanassios, Rümmele, Petra, Lamszus, Katrin, Schulz, Jörg B., Weis, Joachim, Bogdahn, Ulrich, Wischhusen, Jörg, Hau, Peter, Spang, Rainer and Beier, Dagmar (2012) The cancer stem cell subtype determines immune infiltration of glioblastoma. Stem Cells and Development 21 (15), pp. 2753-2761.

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Abstract

Immune cell infiltration varies widely between different glioblastomas (GBMs). The underlying mechanism, however, remains unknown. Here we show that TGF-beta regulates proliferation, migration, and tumorigenicity of mesenchymal GBM cancer stem cells (CSCs) in vivo and in vitro. In contrast, proneural GBM CSCs resisted TGF-beta due to TGFR2 deficiency. In vivo, a substantially increased ...

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Item type:Article
Date:October 2012
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identification Number:
ValueType
19497285PubMed ID
10.1089/scd.2011.0660DOI
Classification:
NotationType
AnimalsMESH
Brain Neoplasms/pathologyMESH
Cell Line, TumorMESH
Cell ProliferationMESH
Gene Expression Regulation, NeoplasticMESH
Glioblastoma/pathologyMESH
HumansMESH
Immunologic Factors/physiologyMESH
MiceMESH
NK Cell Lectin-Like Receptor Subfamily K/metabolismMESH
Neoplasm TransplantationMESH
Neoplastic Stem Cells/pathologyMESH
Oligonucleotide Array Sequence AnalysisMESH
PhosphorylationMESH
Protein Processing, Post-TranslationalMESH
Smad2 Protein/metabolismMESH
T-Lymphocytes, Cytotoxic/pathologyMESH
Transcriptional ActivationMESH
TranscriptomeMESH
Transforming Growth Factor beta/physiologyMESH
Tumor Burden/immunologyMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29168
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