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The cancer stem cell subtype determines immune infiltration of glioblastoma

Beier, Christoph P. ; Kumar, Praveen ; Meyer, Katharina ; Leukel, Petra ; Bruttel, Valentin ; Aschenbrenner, Ines ; Riemenschneider, Markus J. ; Fragoulis, Athanassios ; Rümmele, Petra ; Lamszus, Katrin ; Schulz, Jörg B. ; Weis, Joachim ; Bogdahn, Ulrich ; Wischhusen, Jörg ; Hau, Peter ; Spang, Rainer ; Beier, Dagmar



Abstract

Immune cell infiltration varies widely between different glioblastomas (GBMs). The underlying mechanism, however, remains unknown. Here we show that TGF-beta regulates proliferation, migration, and tumorigenicity of mesenchymal GBM cancer stem cells (CSCs) in vivo and in vitro. In contrast, proneural GBM CSCs resisted TGF-beta due to TGFR2 deficiency. In vivo, a substantially increased ...

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