Go to content
UR Home

The cancer stem cell subtype determines immune infiltration of glioblastoma

Beier, Christoph P. ; Kumar, Praveen ; Meyer, Katharina ; Leukel, Petra ; Bruttel, Valentin ; Aschenbrenner, Ines ; Riemenschneider, Markus J. ; Fragoulis, Athanassios ; Rümmele, Petra ; Lamszus, Katrin ; Schulz, Jörg B. ; Weis, Joachim ; Bogdahn, Ulrich ; Wischhusen, Jörg ; Hau, Peter ; Spang, Rainer ; Beier, Dagmar


Immune cell infiltration varies widely between different glioblastomas (GBMs). The underlying mechanism, however, remains unknown. Here we show that TGF-beta regulates proliferation, migration, and tumorigenicity of mesenchymal GBM cancer stem cells (CSCs) in vivo and in vitro. In contrast, proneural GBM CSCs resisted TGF-beta due to TGFR2 deficiency. In vivo, a substantially increased ...


Owner only: item control page
  1. Homepage UR

University Library

Publication Server


Publishing: oa@ur.de
0941 943 -4239 or -69394

Dissertations: dissertationen@ur.de
0941 943 -3904

Research data: datahub@ur.de
0941 943 -5707

Contact persons