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Transcriptional profiles of CD133+ and CD133- glioblastoma-derived cancer stem cell lines suggest different cells of origin

Lottaz, Claudio ; Beier, Dagmar ; Meyer, Katharina ; Kumar, Praveen ; Hermann, Andreas ; Schwarz, Johannes ; Junker, Markus ; Oefner, Peter J. ; Bogdahn, Ulrich ; Wischhusen, J ; Spang, Rainer ; Storch, Alexander ; Beier, Christoph P.



Abstract

Glioblastoma multiforme (GBM) is paradigmatic for the investigation of cancer stem cells (CSC) in solid tumors. Growing evidence suggests that different types of CSC lead to the formation of GBM. This has prompted the present comparison of gene expression profiles between 17 GBM CSC lines and their different putative founder cells. Using a newly derived 24-gene signature, we can now distinguish ...

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