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Ocular delivery systems for poorly soluble drugs: An in-vivo evaluation

Luschmann, Christoph, Herrmann, W., Strauss, Olaf, Luschmann, Karl and Goepferich, Achim (2013) Ocular delivery systems for poorly soluble drugs: An in-vivo evaluation. International Journal of Pharmaceutics 455 (1-2), pp. 331-337.

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Other URL: http://dx.doi.org/10.1016/j.ijpharm.2013.07.002


Abstract

For highly potent but poorly water-soluble drugs like cyclosporine A, the development of aqueous formulations providing an increase of corneal drug tissue levels, and thus of bioavailability, to increase patient compliance is still a challenge. Therefore, we designed two water-based liquid application systems, an in-situ nanosuspension (INS) and a micellar solution (MS), and tested both ...

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Item type:Article
Date:2013
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)
Identification Number:
ValueType
23867983PubMed ID
Keywords:Bioavailability, Biocompatibility, Cyclosporine A, Dry eye disease, In-situ nanosuspension, Surfactant micelles
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:29270
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