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Ocular delivery systems for poorly soluble drugs: An in-vivo evaluation

Luschmann, Christoph ; Herrmann, W. ; Strauss, Olaf ; Luschmann, Karl ; Goepferich, Achim


For highly potent but poorly water-soluble drugs like cyclosporine A, the development of aqueous formulations providing an increase of corneal drug tissue levels, and thus of bioavailability, to increase patient compliance is still a challenge. Therefore, we designed two water-based liquid application systems, an in-situ nanosuspension (INS) and a micellar solution (MS), and tested both ...


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