Luschmann, Christoph, Herrmann, W., Strauss, Olaf, Luschmann, Karl and Goepferich, Achim (2013) Ocular delivery systems for poorly soluble drugs: An in-vivo evaluation. International Journal of Pharmaceutics 455 (1-2), pp. 331-337.
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Other URL: http://dx.doi.org/10.1016/j.ijpharm.2013.07.002
Abstract
For highly potent but poorly water-soluble drugs like cyclosporine A, the development of aqueous formulations providing an increase of corneal drug tissue levels, and thus of bioavailability, to increase patient compliance is still a challenge. Therefore, we designed two water-based liquid application systems, an in-situ nanosuspension (INS) and a micellar solution (MS), and tested both ...
Export bibliographical data
| Item type: | Article | ||||
|---|---|---|---|---|---|
| Date: | 2013 | ||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) | ||||
| Identification Number: |
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| Keywords: | Bioavailability, Biocompatibility, Cyclosporine A, Dry eye disease, In-situ nanosuspension, Surfactant micelles | ||||
| Dewey Decimal Classification: | 600 Technology > 615 Pharmacy | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 29270 |
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