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Impact of Polyelectrolyte Structure on the Shape of Nanoassemblies with Cationic Peptides

Ferstl, Matthias, Drechsler, Markus, Rachel, Reinhard, Rischer, M., Engel, J., Backofen, Michael and Goepferich, Achim (2013) Impact of Polyelectrolyte Structure on the Shape of Nanoassemblies with Cationic Peptides. European Journal of Pharmaceutical Sciences 102, pp. 2599-2607.

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Abstract

We investigated how the structure of nanofibers, resulting from interactions between anionic polyelectrolytes and cationic peptides, relies on the properties of the polyelectrolyte component. By using hyaluronate (H), carboxymethylcellulose (CMC), xanthan (X), and ozarelix (O), a cationic decapeptide, we determined the influence of characteristic polyelectrolyte parameters such as size and charge ...

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Item type:Article
Date:2013
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)
Identification Number:
ValueType
10.1002/jps.23619DOI
Keywords:calorimetry (ITC); protein formulation; imaging methods; nanotechnology; polyelectrolytes; physical characterization; particle size
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:29274
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