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RNA “Traffic Lights”: An Analytical Tool to Monitor siRNA Integrity

Holzhauser, C. ; Liebl, Renate ; Goepferich, Achim ; Wagenknecht, Hans-Achim ; Breunig, Miriam


The combination of thiazole orange and thiazole red as an internal energy transfer-based fluorophore pair in oligonucleotides provides an outstanding analytical tool to follow DNA/RNA hybridization through a distinct fluorescence color change from red to green. Herein, we demonstrate that this concept can be applied to small interfering RNA (siRNA) to monitor RNA integrity in living cells in real ...


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