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Monitoring the Degradation of Reduction-Sensitive Gene Carriers with Fluorescence Spectroscopy and Flow Cytometry

Hozsa, Constantin, Breunig, Miriam and Goepferich, Achim (2013) Monitoring the Degradation of Reduction-Sensitive Gene Carriers with Fluorescence Spectroscopy and Flow Cytometry. Methods in Molecular Biology 991, pp. 171-184.

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Abstract

Polycations like poly(ethylene imine) (PEI) or poly(l-lysine) (pLL) form nanometer-sized complexes with nucleic acids (polyplexes) which can be used for gene delivery. It is known that the properties of these ­carriers can be greatly improved by introducing disulfide bridges on the polymers, thus making them reduction sensitive. However, little is known about how such modified carriers behave ...

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Item type:Article
Date:2013
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)
Identification Number:
ValueType
10.1007/978-1-62703-336-7_17DOI
Keywords:Poly(ethylene imine); Poly(l-lysine); Redox-sensitive gene carrier; Disulfides; Flow cytometry; BODIPY FL l-cystine; Polyplexes
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:29276
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