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Premature drug release of polymeric micelles and its effects on tumor targeting

Miller, Tobias, Breyer, S., van Colen, G., Mier, W., Haberkorn, U., Geissler, S., Voss, S., Weigandt, Markus and Goepferich, Achim (2013) Premature drug release of polymeric micelles and its effects on tumor targeting. International Journal of Pharmaceutics 445 (1-2), pp. 117-124.

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Abstract

Based on the enhanced permeability and retention (EPR) effect, nanoparticles are believed to accumulate in tumors. In this conjunction, the stability of drug encapsulation is assumed to be sufficient. For clarification purposes, PEGylated poly-(d,l-lactic acid) (PEG-PDLLA) micelles which incorporated the hydrophobic model drug dechloro-4-iodo-fenofibrate (IFF) were investigated. H2N-PEG-PDLLA was ...

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Item type:Article
Date:2013
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)
Identification Number:
ValueType
10.1016/j.ijpharm.2013.01.059DOI
Keywords:Polymeric micelles; Organ distribution; Bioimaging; Tumor accumulation; EPR effect; Premature release
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:29279
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