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Premature drug release of polymeric micelles and its effects on tumor targeting

Miller, Tobias ; Breyer, S. ; van Colen, G. ; Mier, W. ; Haberkorn, U. ; Geissler, S. ; Voss, S. ; Weigandt, Markus ; Goepferich, Achim



Abstract

Based on the enhanced permeability and retention (EPR) effect, nanoparticles are believed to accumulate in tumors. In this conjunction, the stability of drug encapsulation is assumed to be sufficient. For clarification purposes, PEGylated poly-(d,l-lactic acid) (PEG-PDLLA) micelles which incorporated the hydrophobic model drug dechloro-4-iodo-fenofibrate (IFF) were investigated. H2N-PEG-PDLLA was ...

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