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Lactate promotes glioma migration by TGF-beta2-dependent regulation of matrix metalloproteinase-2

Baumann, Fusun ; Leukel, Petra ; Doerfelt, Anett ; Beier, Christoph P. ; Dettmer, Katja ; Oefner, Peter J. ; Kastenberger, Michael ; Kreutz, Marina ; Nickl-Jockschat, Thomas ; Bogdahn, Ulrich ; Bosserhoff, Anja-Katrin ; Hau, Peter



Abstract

Lactate dehydrogenase type A (LDH-A) is a key metabolic enzyme catalyzing pyruvate into lactate and is excessively expressed by tumor cells. Transforming growth factor-beta2 (TGF-beta2) is a key regulator of invasion in high-grade gliomas, partially by inducing a mesenchymal phenotype and by remodeling the extracellular matrix. In this study, we tested the hypothesis that lactate metabolism ...

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