Go to content
UR Home

Lactate promotes glioma migration by TGF-beta2-dependent regulation of matrix metalloproteinase-2

Baumann, Fusun, Leukel, Petra, Doerfelt, Anett, Beier, Christoph P., Dettmer, Katja, Oefner, Peter J., Kastenberger, Michael, Kreutz, Marina, Nickl-Jockschat, Thomas, Bogdahn, Ulrich, Bosserhoff, Anja-Katrin and Hau, Peter (2009) Lactate promotes glioma migration by TGF-beta2-dependent regulation of matrix metalloproteinase-2. Neuro-oncology 11 (4), pp. 368-380.

Full text not available from this repository.

at PubMed

at publisher (via DOI)


Abstract

Lactate dehydrogenase type A (LDH-A) is a key metabolic enzyme catalyzing pyruvate into lactate and is excessively expressed by tumor cells. Transforming growth factor-beta2 (TGF-beta2) is a key regulator of invasion in high-grade gliomas, partially by inducing a mesenchymal phenotype and by remodeling the extracellular matrix. In this study, we tested the hypothesis that lactate metabolism ...

plus


Export bibliographical data



Item type:Article
Date:2009
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
18510920PubMed ID
10.1215/15228517-2008-106DOI
Classification:
NotationType
Brain Neoplasms/pathologyMESH
Cell MovementMESH
Enzyme-Linked Immunosorbent AssayMESH
Flow CytometryMESH
Gene Expression Regulation, NeoplasticMESH
Glioma/pathologyMESH
Glucose/analysisMESH
HumansMESH
Integrin alphaVbeta3/metabolismMESH
Isoenzymes/physiologyMESH
L-Lactate Dehydrogenase/physiologyMESH
Matrix Metalloproteinase 2/metabolismMESH
Matrix Metalloproteinase InhibitorsMESH
RNA, Messenger/metabolismMESH
RNA, Small Interfering/pharmacologyMESH
Reverse Transcriptase Polymerase Chain ReactionMESH
Spectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationMESH
Transforming Growth Factor beta2/metabolismMESH
Tumor Cells, CulturedMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29313
Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons