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Binding of Ligands to GPCRs – How Valid is a Thermodynamic
Discrimination of Antagonists and Agonists?

Strasser, Andrea and Wittmann, Hans-Joachim (2012) Binding of Ligands to GPCRs – How Valid is a Thermodynamic
Discrimination of Antagonists and Agonists?
Journal of Physical Chemistry & Biophysics 2012.

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Abstract

Abstract In 1979, a thermodynamic discrimination between antagonists and agonists at GPCRs was discussed in literature for the first time. Subsequently a small number of experimental studies, addressing not only Gibbs energy but also enthalpy and entropy of ligand binding were performed within the last 30 years at different GPCRs. Some of these studies support the suggested “thermodynamic ...

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Item type:Article
Date:2012
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz)
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.4172/2161-0398.S1-001DOI
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:29508
Owner only: item control page

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