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Synthesis and biological activity of functionalized photochromic dithienylethenes

Kuzmanovic, Natascha (2015) Synthesis and biological activity of functionalized photochromic dithienylethenes. Dissertationsreihe der Fakultät für Chemie und Pharmazie der Universität Regensburg 1, PhD, Universität Regensburg.

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Date of publication of this fulltext: 02 Jun 2015 10:50

Abstract (English)

This thesis focuses on the design, synthesis and evaluation of novel functionalized photochromic dithienylethenes (DTEs) for applications in biology. Chapter 1 deals with the creation of dithienylcyclopentene based enzyme inhibitors to reversibly control the activity of the metabolic branch-point enzyme PriA from Myco-bacterium tuberculosis (mtPriA) by light. The enzyme’s natural rotational ...

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Translation of the abstract (German)

Diese Arbeit befasst sich mit der Gestaltung, der Synthese und der Untersuchung von neuen funktionalisierten photochromen Dithienylethenen (DTEs) für biologische Anwendungen. Kapitel 1 handelt von der Entwicklung von Dithienylcyclopenten basierten Enzyminhibitoren, die die Aktivität des metabolischen Schlüsselenzyms PriA aus Mycobacterium tuberculosis (mtPriA) reversibel durch Licht kontrollieren ...

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Item type:Thesis of the University of Regensburg (PhD)
Series of the University of Regensburg:Dissertationsreihe der Fakultät für Chemie und Pharmazie der Universität Regensburg
Date:2 June 2015
Referee:Prof. Dr. Burkhard König
Date of exam:14 February 2014
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Keywords:photochromism, dithienylethenes, enzyme inhibitors
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:29952
Owner only: item control page

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