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Synthese und funktionelle In-vitro-Pharmakologie neuer Liganden des 5-HT2A-Rezeptors aus der Klasse der Tryptamine

Helm, Klaus (2015) Synthese und funktionelle In-vitro-Pharmakologie neuer Liganden des 5-HT2A-Rezeptors aus der Klasse der Tryptamine. PhD, Universität Regensburg.

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Date of publication of this fulltext: 02 Jun 2015 11:48

Abstract (German)

G-Protein-gekoppelte Rezeptoren (GPCR), zu denen die vier Histamin-Rezeptoren und bis auf die 5-HT3-Rezeptoren auch alle Serotonin-Rezeptoren zählen, gehören zu den wichtigsten Zielproteinen für Arzneistoffe. Rund 30 % aller derzeit zugelassenen und angewandten Medikamente wirken durch GPCR-Bindung. Der 5-HT2A-Rezeptor spielt eine zentrale Rolle bei Schizophrenie, Depressionen und ...

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Translation of the abstract (English)

G-protein coupled receptors (GPCR) are one of the most important target proteins for drugs. All four histamine receptors and except the 5-HT3-family all serotonin receptors are GPCRs. Around 30 % of all currently used act via GPCR-binding. The 5-HT2A-receptor plays an important role in schizophrenia, depression and anxiety disorders. It also contributes to wound closure and it’s involved in ...

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Export bibliographical data



Item type:Thesis of the University of Regensburg (PhD)
Date:2 June 2015
Referee:Prof. Dr. Sigurd Elz and Prof. Dr. Siavosh Mahboobi
Date of exam:25 June 2014
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz)
Keywords:Serotonin, 5-HT2A-Rezeptor, Tryptaminderivat, In-vitro-Pharmakologie, Rattenschwanzarterie, ventrale Kaudalarterie, Histamin-H1-Rezeptor, Ketanserin, G-Protein-gekoppelter-Rezeptor, GPCR, Tryptamine derivative, 5-HT2A receptor, rat tail artery, affinity, intrinsic activity
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:30387
Owner only: item control page

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