Abstract
Malignant melanoma is thought to exhibit a high base mutation rate compared with other solid tumors. Therefore, there is a strong interest in discovering new mutations and understanding their impact on melanoma pathogenesis. Mutations in several genes such as BRAF, NRAS or KIT are associated with melanoma development and progression. The most common BRAF mutation, BRAF V600E, results in the ...
Abstract
Malignant melanoma is thought to exhibit a high base mutation rate compared with other solid tumors. Therefore, there is a strong interest in discovering new mutations and understanding their impact on melanoma pathogenesis. Mutations in several genes such as BRAF, NRAS or KIT are associated with melanoma development and progression. The most common BRAF mutation, BRAF V600E, results in the constitutive activation of MAPK/ERK signaling in the tumor cells affecting cell division and differentiation. Moreover, previous studies have shown that allele variations of the CDKN2A gene and OCA2 gene are associated with melanoma susceptibility.
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