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Transcriptome sequencing of melanocytic nevi and melanomas from Grm1 transgenic mice to determine melanoma driver mutations

del Jel, Miriam M. ; Engelmann, Julia ; Kunz, Manfred ; Schiffner, Susanne ; Kuphal, Silke ; Bosserhoff, Anja



Abstract

Malignant melanoma is thought to exhibit a high base mutation rate compared with other solid tumors. Therefore, there is a strong interest in discovering new mutations and understanding their impact on melanoma pathogenesis. Mutations in several genes such as BRAF, NRAS or KIT are associated with melanoma development and progression. The most common BRAF mutation, BRAF V600E, results in the ...

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