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Transcriptome sequencing of melanocytic nevi and melanomas from Grm1 transgenic mice to determine melanoma driver mutations

del Jel, Miriam M., Engelmann, Julia, Kunz, Manfred, Schiffner, Susanne, Kuphal, Silke and Bosserhoff, Anja (2014) Transcriptome sequencing of melanocytic nevi and melanomas from Grm1 transgenic mice to determine melanoma driver mutations. Pigment Cell & Melanoma Research 27, pp. 678-680.

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Other URL: http://onlinelibrary.wiley.com/doi/10.1111/pcmr.12244/abstract;jsessionid=1234D6FF30B226EB36AA9FB170F74F0F.f02t04


Abstract

Malignant melanoma is thought to exhibit a high base mutation rate compared with other solid tumors. Therefore, there is a strong interest in discovering new mutations and understanding their impact on melanoma pathogenesis. Mutations in several genes such as BRAF, NRAS or KIT are associated with melanoma development and progression. The most common BRAF mutation, BRAF V600E, results in the ...

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Item type:Article
Date:April 2014
Additional Information (public):Article first published online: 7 APR 2014
Institutions:Medicine > Lehrstuhl für Pathologie
Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identification Number:
ValueType
10.1111/pcmr.12244DOI
24661573PubMed ID
Dewey Decimal Classification:000 Computer science, information & general works > 004 Computer science
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30481
Owner only: item control page
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