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Central European BRCA2 mutation carriers: Birth cohort status correlates with onset of breast cancer

Tea, Muy-Kheng M. ; Kroiss, Regina ; Muhr, Daniela ; Fuerhauser-Rappaport, Christine ; Oefner, Peter J. ; Wagner, Teresa M ; Singer, Christian F.



Abstract

Background Mutations in brca1 and 2 genes lead to a significant increase in the lifetime risk of developing breast (BC) and ovarian cancer (OC). There are indications that birth cohort can influence the cancer risk in brca1 mutation carriers. Therefore, we investigated the risks for BC and OC associated with brca2 mutations in a cohort of female mutation carriers of a genetically heterogeneous ...

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