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Central European BRCA2 mutation carriers: Birth cohort status correlates with onset of breast cancer

Tea, Muy-Kheng M., Kroiss, Regina, Muhr, Daniela, Fuerhauser-Rappaport, Christine, Oefner, Peter J., Wagner, Teresa M and Singer, Christian F. (2013) Central European BRCA2 mutation carriers: Birth cohort status correlates with onset of breast cancer. Maturitas.

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Abstract

Background Mutations in brca1 and 2 genes lead to a significant increase in the lifetime risk of developing breast (BC) and ovarian cancer (OC). There are indications that birth cohort can influence the cancer risk in brca1 mutation carriers. Therefore, we investigated the risks for BC and OC associated with brca2 mutations in a cohort of female mutation carriers of a genetically heterogeneous ...

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Item type:Article
Date:October 2013
Additional Information (public):printed Volume 77, Issue 1, January 2014, Pages 68–72
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
10.1016/j.maturitas.2013.09.012DOI
24156927PubMed ID
Keywords:BRCA2; Breast cancer risk; Hereditary breast and ovarian cancer; Penetrance of BRCA2
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30483
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