; Damm-Welk, Christine ; Drexler, H. G. ; Hummel, Michael ; Jaffe, Elaine S.
; Kueppers, Ralf ; Lefebvre, Christine
; Lisfeld, Jasmin ; Loeffler, Markus ; Mcleod, Roderick A. ; Nagel, Inga ; Oschlies, Ilske ; Rosolowski, Maciej ; Russell, Robert B.
; Rymkiewicz, Grzegorz ; Schindler, Detlev ; Schlesner, Matthias
; Scholtysik, Rene ; Schwaenen, Carsten ; Spang, Rainer ; Szczepanowski, Monika ; Truemper, Lorenz ; Vater, Inga ; Wessendorf, Swen ; Klapper, Wolfram ; Siebert, Rainer | Item type: | Article | ||||||
|---|---|---|---|---|---|---|---|
| Journal or Publication Title: | Blood | ||||||
| Publisher: | AMER SOC HEMATOLOGY | ||||||
| Place of Publication: | WASHINGTON | ||||||
| Volume: | 123 | ||||||
| Page Range: | pp. 1187-1198 | ||||||
| Date: | January 2014 | ||||||
| Additional Information (public): | Prepublished online as Blood First Edition paper, January 7, 2014 | ||||||
| Institutions: | Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang) Informatics and Data Science > Department Computational Life Science > Lehrstuhl für Statistische Bioinformatik (Prof. Spang) | ||||||
| Identification Number: |
| ||||||
| Keywords: | NON-HODGKINS-LYMPHOMA; FOLLICULAR LYMPHOMAS; TUMOR-SUPPRESSOR; GENE; MUTATIONS; GENOME; HYBRIDIZATION; ABNORMALITIES; DEREGULATION; PATHOGENESIS; | ||||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine | ||||||
| Status: | Published | ||||||
| Refereed: | Yes, this version has been refereed | ||||||
| Created at the University of Regensburg: | Partially | ||||||
| Item ID: | 30488 |
Abstract
The genetic hallmark of Burkitt lymphoma (BL) is the t(8;14)(q24;q32) and its variants leading to activation of the MYC oncogene. It is a matter of debate whether true BL without MYC translocation exists. Here, we identified 59 lymphomas concordantly called BL by 2 gene expression classifiers among 753 B-cell lymphomas. Only2 (3%) of these 59 molecular BL lacked a MYC translocation, which both ...

Abstract
The genetic hallmark of Burkitt lymphoma (BL) is the t(8;14)(q24;q32) and its variants leading to activation of the MYC oncogene. It is a matter of debate whether true BL without MYC translocation exists. Here, we identified 59 lymphomas concordantly called BL by 2 gene expression classifiers among 753 B-cell lymphomas. Only2 (3%) of these 59 molecular BL lacked a MYC translocation, which both shared a peculiar pattern of chromosome 11q aberration characterized by interstitial gains including 11q23.2-q23.3 and telomeric losses of 11q24.1-qter. We extended our analysis to 17 MYC-negative high-grade B-cell lymphomas with a similar 11q aberration and showed this aberration to be recurrently associated with morphologic and clinical features of BL. The minimal region of gain was defined by high-level amplifications in 11q23.3 and associated with overexpression of genes including PAFAH1B2 on a transcriptional and protein level. The recurrent region of loss contained a focal homozygous deletion in 11q24.2-q24.3 including the ETS1 gene, which was shown to be mutated in 4 of 16 investigated cases. These findings indicate the existence of a molecularly distinct subset of B-cell lymphomas reminiscent of BL, which is characterized by deregulation of genes in 11q.
Metadata last modified: 29 Sep 2021 07:40
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