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A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma

Salaverria, Itziar ; Martin-Guerrero, Idoia ; Wagener, Rabea ; Kreuz, Markus ; Kohler, Christian ; Richter, Julia ; Pienkowska-Grela, Barbara ; Adam, Patrick ; Burkhardt, Birgit ; Claviez, Alexander ; Damm-Welk, Christine ; Drexler, H. G. ; Hummel, Michael ; Jaffe, Elaine S. ; Kueppers, Ralf ; Lefebvre, Christine ; Lisfeld, Jasmin ; Loeffler, Markus ; Mcleod, Roderick A. ; Nagel, Inga ; Oschlies, Ilske ; Rosolowski, Maciej ; Russell, Robert B. ; Rymkiewicz, Grzegorz ; Schindler, Detlev ; Schlesner, Matthias ; Scholtysik, Rene ; Schwaenen, Carsten ; Spang, Rainer ; Szczepanowski, Monika ; Truemper, Lorenz ; Vater, Inga ; Wessendorf, Swen ; Klapper, Wolfram ; Siebert, Rainer



Abstract

The genetic hallmark of Burkitt lymphoma (BL) is the t(8;14)(q24;q32) and its variants leading to activation of the MYC oncogene. It is a matter of debate whether true BL without MYC translocation exists. Here, we identified 59 lymphomas concordantly called BL by 2 gene expression classifiers among 753 B-cell lymphomas. Only 2 (3%) of these 59 molecular BL lacked a MYC translocation, which both ...

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