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- URN zum Zitieren dieses Dokuments:
- urn:nbn:de:bvb:355-epub-304949
- DOI zum Zitieren dieses Dokuments:
- 10.5283/epub.30494
Zusammenfassung
Short interfering RNAs (siRNAs) are widely used as tool for gene inactivation in basic research and therapeutic applications. One of the major shortcomings of siRNA experiments are sequence-specific off-target effects. Such effects are largely unpredictable because siRNAs can affect partially complementary sequences and function like microRNAs (miRNAs), which inhibit gene expression on mRNA ...
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