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Regulation and function of the atypical cadherin FAT1 in hepatocellular carcinoma

Valletta, Daniela, Czech, Barbara, Spruss, Thilo, Ikenberg, Kristian, Wild, Peter J., Hartmann, Arndt, Weiss, Thomas S., Oefner, Peter J., Müller, Martina, Bosserhoff, Anja-Katrin and Hellerbrand, Claus (2014) Regulation and function of the atypical cadherin FAT1 in hepatocellular carcinoma. Carcinogenesis 35, pp. 1407-1415.

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Abstract

In human cancers, giant cadherin FAT1 may function both, as an oncogene and a tumor suppressor. Here, we investigated the expression and function of FAT1 in hepatocellular carcinoma (HCC). FAT1 expression was increased in human HCC cell lines and tissues compared with primary human hepatocytes and non-tumorous liver tissue as assessed by quantitative PCR and western blot analysis. Combined ...

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Item type:Article
Date:3 March 2014
Additional Information (public):First published online: March 3, 2014
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
10.1093/carcin/bgu054DOI
24590895PubMed ID
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30495
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