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Regulation and function of the atypical cadherin FAT1 in hepatocellular carcinoma

Valletta, Daniela ; Czech, Barbara ; Spruss, Thilo ; Ikenberg, Kristian ; Wild, Peter J. ; Hartmann, Arndt ; Weiss, Thomas S. ; Oefner, Peter J. ; Müller, Martina ; Bosserhoff, Anja-Katrin ; Hellerbrand, Claus



Abstract

In human cancers, giant cadherin FAT1 may function both, as an oncogene and a tumor suppressor. Here, we investigated the expression and function of FAT1 in hepatocellular carcinoma (HCC). FAT1 expression was increased in human HCC cell lines and tissues compared with primary human hepatocytes and non-tumorous liver tissue as assessed by quantitative PCR and western blot analysis. Combined ...

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