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Presenilin1/gamma-secretase modulates P-cadherin processing and influences cell adhesion in oral squamous cell carcinoma cell lines

Bauer, Karin, Gosau, Martin, Reinders, Jörg, Oefner, Peter J., Reichert, Torsten E. and Bauer, Richard (2013) Presenilin1/gamma-secretase modulates P-cadherin processing and influences cell adhesion in oral squamous cell carcinoma cell lines. Carcinogenesis 34, pp. 2622-2628.

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Abstract

P-cadherin belongs to a family of Ca2+-dependent homophilic cell–cell adhesion proteins that are important for correct cellular localization and tissue integrity in the oral epithelium. P-cadherin is only expressed in the basal and suprabasal cell layers of the oral epithelium, but in advanced oral squamous cell carcinoma (OSCC), a reduced membranous and an enhanced cytoplasmic truncated ...

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Item type:Article
Date:31 May 2013
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
10.1093/carcin/bgt211DOI
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:30512
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