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Presenilin1/gamma-secretase modulates P-cadherin processing and influences cell adhesion in oral squamous cell carcinoma cell lines

Bauer, Karin ; Gosau, Martin ; Reinders, Jörg ; Oefner, Peter J. ; Reichert, Torsten E. ; Bauer, Richard



Abstract

P-cadherin belongs to a family of Ca2+-dependent homophilic cell–cell adhesion proteins that are important for correct cellular localization and tissue integrity in the oral epithelium. P-cadherin is only expressed in the basal and suprabasal cell layers of the oral epithelium, but in advanced oral squamous cell carcinoma (OSCC), a reduced membranous and an enhanced cytoplasmic truncated ...

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