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Chirasani, Sridhar Reddy ; Leukel, Petra ; Gottfried, Eva ; Hochrein, Jochen ; Stadler, Katrin ; Neumann, Bernhard ; Oefner, Peter J. ; Gronwald, Wolfram ; Bogdahn, Ulrich ; Hau, Peter ; Kreutz, Marina ; Grauer, Oliver M.

Diclofenac inhibits lactate formation and efficiently counteracts local immune suppression in a murine glioma model

Chirasani, Sridhar Reddy, Leukel, Petra, Gottfried, Eva, Hochrein, Jochen, Stadler, Katrin, Neumann, Bernhard, Oefner, Peter J. , Gronwald, Wolfram, Bogdahn, Ulrich, Hau, Peter, Kreutz, Marina and Grauer, Oliver M. (2013) Diclofenac inhibits lactate formation and efficiently counteracts local immune suppression in a murine glioma model. International Journal of Cancer 132 (4), pp. 843-853.

Date of publication of this fulltext: 31 Jul 2014 12:58
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Details

Item typeArticle
Journal or Publication TitleInternational Journal of Cancer
Publisher:WILEY-BLACKWELL
Place of Publication:HOBOKEN
Volume:132
Number of Issue or Book Chapter:4
Page Range:pp. 843-853
Date15 February 2013
InstitutionsMedicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Medicine > Lehrstuhl für Neurologie
Identification Number
ValueType
22752934PubMed ID
10.1002/ijc.27712DOI
Classification
NotationType
AnimalsMESH
Anti-Inflammatory Agents, Non-Steroidal/pharmacologyMESH
Bone Marrow Cells/metabolismMESH
Brain Neoplasms/metabolismMESH
Cell Cycle Checkpoints/drug effectsMESH
Cell Line, TumorMESH
Cell Proliferation/drug effectsMESH
Dendritic Cells/metabolismMESH
Diclofenac/pharmacologyMESH
Disease Models, AnimalMESH
FemaleMESH
Glioma/metabolismMESH
Imidazoles/pharmacologyMESH
Immune ToleranceMESH
Interferon-gamma/biosynthesisMESH
Interleukin-10/biosynthesisMESH
Interleukin-12/biosynthesisMESH
Interleukin-2 Receptor alpha Subunit/biosynthesisMESH
Isoenzymes/metabolismMESH
L-Lactate Dehydrogenase/metabolismMESH
Lactic Acid/metabolismMESH
Lymphocyte ActivationMESH
MiceMESH
Mice, Inbred C57BLMESH
PhosphorylationMESH
T-Lymphocytes, Regulatory/metabolismMESH
Transcriptional ActivationMESH
Up-RegulationMESH
KeywordsREGULATORY T-CELLS; GROWTH IN-VIVO; DENDRITIC CELLS; TUMOR-GROWTH; POOR-PROGNOSIS; C-MYC; CYCLOOXYGENASE-2; EXPRESSION; RESPONSES; HYPOXIA; diclofenac; lactate; LDH-A; Stat3; dendritic cell; TLR; regulatory T cell; glioma
Dewey Decimal Classification600 Technology > 610 Medical sciences Medicine
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
StatusPublished
RefereedYes, this version has been refereed
Created at the University of RegensburgYes
Item ID30515

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