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Diclofenac inhibits lactate formation and efficiently counteracts local immune suppression in a murine glioma model

Chirasani, Sridhar Reddy ; Leukel, Petra ; Gottfried, Eva ; Hochrein, Jochen ; Stadler, Katrin ; Neumann, Bernhard ; Oefner, Peter J. ; Gronwald, Wolfram ; Bogdahn, Ulrich ; Hau, Peter ; Kreutz, Marina ; Grauer, Oliver M.



Abstract

Lactate formation in highly proliferative tumors such as malignant gliomas is associated with poor survival and contributes to the suppression of local immunity. Here, we report that diclofenac used at nontoxic concentrations significantly decreased lactate production in murine glioma cells and inhibited the expression of lactate dehydrogenase-A in vitro. Lactate reduction was accompanied by a ...

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