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Diclofenac inhibits lactate formation and efficiently counteracts local immune suppression in a murine glioma model

Chirasani, Sridhar Reddy, Leukel, Petra, Gottfried, Eva, Hochrein, Jochen, Stadler, Katrin, Neumann, Bernhard, Oefner, Peter J., Gronwald, Wolfram, Bogdahn, Ulrich, Hau, Peter, Kreutz, Marina and Grauer, Oliver M. (2013) Diclofenac inhibits lactate formation and efficiently counteracts local immune suppression in a murine glioma model. International Journal of Cancer 132 (4), pp. 843-853.

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Abstract

Lactate formation in highly proliferative tumors such as malignant gliomas is associated with poor survival and contributes to the suppression of local immunity. Here, we report that diclofenac used at nontoxic concentrations significantly decreased lactate production in murine glioma cells and inhibited the expression of lactate dehydrogenase-A in vitro. Lactate reduction was accompanied by a ...

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Item type:Article
Date:15 February 2013
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
22752934PubMed ID
10.1002/ijc.27712DOI
Classification:
NotationType
AnimalsMESH
Anti-Inflammatory Agents, Non-Steroidal/pharmacologyMESH
Bone Marrow Cells/metabolismMESH
Brain Neoplasms/metabolismMESH
Cell Cycle Checkpoints/drug effectsMESH
Cell Line, TumorMESH
Cell Proliferation/drug effectsMESH
Dendritic Cells/metabolismMESH
Diclofenac/pharmacologyMESH
Disease Models, AnimalMESH
FemaleMESH
Glioma/metabolismMESH
Imidazoles/pharmacologyMESH
Immune ToleranceMESH
Interferon-gamma/biosynthesisMESH
Interleukin-10/biosynthesisMESH
Interleukin-12/biosynthesisMESH
Interleukin-2 Receptor alpha Subunit/biosynthesisMESH
Isoenzymes/metabolismMESH
L-Lactate Dehydrogenase/metabolismMESH
Lactic Acid/metabolismMESH
Lymphocyte ActivationMESH
MiceMESH
Mice, Inbred C57BLMESH
PhosphorylationMESH
T-Lymphocytes, Regulatory/metabolismMESH
Transcriptional ActivationMESH
Up-RegulationMESH
Keywords:diclofenac; lactate; LDH-A; Stat3; dendritic cell; TLR; regulatory T cell; glioma
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:30515
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