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Analysis of human urine reveals metabolic changes related to the development of acute kidney injury following cardiac surgery

Zacharias, Helena ; Schley, Gunnar ; Hochrein, Jochen ; Klein, Matthias S. ; Köberle, Carmen ; Eckardt, Kai-Uwe ; Willam, Carsten ; Oefner, Peter J. ; Gronwald, Wolfram


Acute kidney injury (AKI) is a frequent complication of sepsis, major surgery or nephrotoxic medication use. It is associated with high morbidity and mortality. In an effort to identify novel biomarkers capable of predicting the development of AKI after cardiac surgery with cardiopulmonary bypass use, urine specimens were collected before and at 4 and 24 h after surgery from 106 patients and ...


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