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N-cadherin promoter polymorphisms and risk of osteoarthritis

URN to cite this document:
urn:nbn:de:bvb:355-epub-305300
Ruedel, Anke ; Stark, Klaus ; Kaufmann, Simone ; Bauer, Richard ; Reinders, Jörg ; Rovensky, Jozef ; Blazicková, Stanislava ; Oefner, Peter J. ; Bosserhoff, Anja Katrin
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Date of publication of this fulltext: 05 Aug 2014 09:33


Abstract

Osteoarthritis (OA) is the most common form of arthritis. It is characterized by cartilage destruction and bone remodeling, mediated in part by synovial fibroblasts (SFs). Given the functional significance of cadherins in these cells, we aimed at determining the role of genetic variants of N-cadherin (CDH2) in OA of the knee and hip. Six single-nucleotide polymorphisms in the genomic region of ...

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