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N-cadherin promoter polymorphisms and risk of osteoarthritis

Ruedel, Anke, Stark, Klaus, Kaufmann, Simone, Bauer, Richard, Reinders, Jörg, Rovensky, Jozef, Blazicková, Stanislava, Oefner, Peter J. and Bosserhoff, Anja Katrin (2014) N-cadherin promoter polymorphisms and risk of osteoarthritis. FASEB journal 28 (2), pp. 683-691.

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Date of publication of this fulltext: 05 Aug 2014 09:33

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Abstract

Osteoarthritis (OA) is the most common form of arthritis. It is characterized by cartilage destruction and bone remodeling, mediated in part by synovial fibroblasts (SFs). Given the functional significance of cadherins in these cells, we aimed at determining the role of genetic variants of N-cadherin (CDH2) in OA of the knee and hip. Six single-nucleotide polymorphisms in the genomic region of ...

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Item type:Article
Date:February 2014
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
24148886PubMed ID
10.1096/fj.13-238295DOI
Classification:
NotationType
AdultMESH
AgedMESH
Aged, 80 and overMESH
Binding Sites/physiologyMESH
Cadherins/geneticsMESH
Cells, CulturedMESH
Chromatin ImmunoprecipitationMESH
Electrophoretic Mobility Shift AssayMESH
Enzyme-Linked Immunosorbent AssayMESH
FemaleMESH
GenotypeMESH
HumansMESH
MaleMESH
Middle AgedMESH
Osteoarthritis/geneticsMESH
Polymorphism, Genetic/geneticsMESH
Promoter Regions, Genetic/geneticsMESH
Reverse Transcriptase Polymerase Chain ReactionMESH
Young AdultMESH
Keywords:CDH2; genetic association study; hnRNP K; rs11564299
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30530
Owner only: item control page

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