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Changes in the hepatic mitochondrial and membrane proteome in mice fed a non-alcoholic steatohepatitis inducing diet.

Thomas, Anja ; Klein, Matthias S. ; Stevens, Axel Peter ; Reinders, Yvonne ; Hellerbrand, Claus ; Dettmer, Katja ; Gronwald, Wolfram ; Oefner, Peter J. ; Reinders, Jörg



Abstract

Non-alcoholic steatohepatitis (NASH) accounts for a large proportion of cryptic cirrhosis in the Western societies. Nevertheless, we lack a deeper understanding of the underlying pathomolecular processes, particularly those preceding hepatic inflammation and fibrosis. In order to gain novel insights into early NASH-development from the first appearance of proteomic alterations to the onset of ...

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