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H2rs: Deducing evolutionary and functionally important residue positions by means of an entropy and similarity based analysis of multiple sequence alignments

Janda, Jan-Oliver, Popal, Ajmal, Bauer, Jochen, Busch, Markus, Klocke, Michael, Spitzer, Wolfgang, Keller, Jörg and Merkl, Rainer (2014) H2rs: Deducing evolutionary and functionally important residue positions by means of an entropy and similarity based analysis of multiple sequence alignments. BMC Bioinformatics 15 (118).

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Abstract

Background The identification of functionally important residue positions is an important task of computational biology. Methods of correlation analysis allow for the identification of pairs of residue positions, whose occupancy is mutually dependent due to constraints imposed by protein structure or function. A common measure assessing these dependencies is the mutual information, which is based ...

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Item type:Article
Date:27 April 2014
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Rainer Merkl
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1186/1471-2105-15-118DOI
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:30549
Owner only: item control page

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