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LMX1B is essential for the maintenance of differentiated podocytes in adult kidneys

Burghardt, Tillmann ; Kastner, Jürgen ; Suleiman, Hani ; Rivera-Milla, Eric ; Stepanova, Natalya ; Lottaz, Claudio ; Kubitza, Marion ; Böger, Carsten A. ; Schmidt, Sarah ; Gorski, Mathias ; de Vries, Uwe ; Schmidt, Helga ; Hertting, Irmgard ; Kopp, Jeffrey ; Rascle, Anne ; Moser, Markus ; Heid, Iris M. ; Warth, Richard ; Spang, Rainer ; Wegener, Joachim ; Mierke, Claudia T. ; Englert, Christoph ; Witzgall, Ralph



Abstract

Mutations of the LMX1B gene cause nail-patella syndrome, a rare autosomal-dominant disorder affecting the development of the limbs, eyes, brain, and kidneys. The characterization of conventional Lmx1b knockout mice has shown that LMX1B regulates the development of podocyte foot processes and slit diaphragms, but studies using podocyte-specific Lmx1b knockout mice have yielded conflicting results ...

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