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LMX1B is essential for the maintenance of differentiated podocytes in adult kidneys

Burghardt, Tillmann, Kastner, Jürgen, Suleiman, Hani, Rivera-Milla, Eric, Stepanova, Natalya, Lottaz, Claudio, Kubitza, Marion, Böger, Carsten A., Schmidt, Sarah, Gorski, Mathias, de Vries, Uwe, Schmidt, Helga, Hertting, Irmgard, Kopp, Jeffrey, Rascle, Anne, Moser, Markus, Heid, Iris M., Warth, Richard, Spang, Rainer, Wegener, Joachim, Mierke, Claudia T., Englert, Christoph and Witzgall, Ralph (2013) LMX1B is essential for the maintenance of differentiated podocytes in adult kidneys. Journal of the American Society of Nephrology : JASN 24 (11), pp. 1830-1848.

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Abstract

Mutations of the LMX1B gene cause nail-patella syndrome, a rare autosomal-dominant disorder affecting the development of the limbs, eyes, brain, and kidneys. The characterization of conventional Lmx1b knockout mice has shown that LMX1B regulates the development of podocyte foot processes and slit diaphragms, but studies using podocyte-specific Lmx1b knockout mice have yielded conflicting results ...

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Item type:Article
Date:November 2013
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
23990680PubMed ID
10.1681/ASN.2012080788DOI
Classification:
NotationType
Actins/physiologyMESH
AgingMESH
AnimalsMESH
ApoptosisMESH
Cell DifferentiationMESH
Collagen Type IV/geneticsMESH
Intracellular Signaling Peptides and Proteins/geneticsMESH
LIM-Homeodomain Proteins/physiologyMESH
Membrane Proteins/geneticsMESH
MiceMESH
Mice, Inbred C57BLMESH
Nail-Patella Syndrome/etiologyMESH
Oligonucleotide Array Sequence AnalysisMESH
Podocytes/ultrastructureMESH
Proteinuria/etiologyMESH
Transcription Factors/physiologyMESH
ZebrafishMESH
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30566
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