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Patient age at diagnosis is associated with the molecular characteristics of diffuse large B-cell lymphoma

Klapper, Wolfram, Kreuz, Markus, Kohler, Christian, Burkhardt, Birgit, Szczepanowski, Monika, Salaverria, Itziar, Hummel, Michael, Loeffler, Markus, Pellissery, Shoji, Woessmann, Wilhelm, Schwänen, Carsten, Trümper, Lorenz, Wessendorf, Swen, Spang, Rainer, Hasenclever, Dirk and Siebert, Reiner (2012) Patient age at diagnosis is associated with the molecular characteristics of diffuse large B-cell lymphoma. Blood 119 (8), pp. 1882-1887.

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Diffuse large B-cell lymphoma is the most frequent type of B-cell lymphoma in adult patients but also occurs in children. Patients are currently assigned to therapy regimens based on arbitrarily chosen age limits only (eg, 18 or 60 years) and not biologically justified limits. A total of 364 diffuse large B-cell lymphomas and related mature aggressive B-cell lymphomas other than Burkitt lymphoma ...


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Item type:Article
Date:February 2012
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identification Number:
22238326PubMed ID
Age FactorsMESH
Analysis of VarianceMESH
Antineoplastic Combined Chemotherapy Protocols/therapeutic useMESH
Chromosome AberrationsMESH
Comparative Genomic HybridizationMESH
DNA-Binding Proteins/metabolismMESH
Gene Expression ProfilingMESH
Gene Expression Regulation, LeukemicMESH
In Situ Hybridization, FluorescenceMESH
Linear ModelsMESH
Lymphoma, Large B-Cell, Diffuse/geneticsMESH
Middle AgedMESH
Outcome Assessment (Health Care)/methodsMESH
Polycomb Repressive Complex 2MESH
Proto-Oncogene Proteins c-bcl-2/metabolismMESH
Transcription Factors/metabolismMESH
Young AdultMESH
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30570
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