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van der Goot, Annemieke ; Zhu, Wentao ; Vázquez-Manrique, Rafael ; Seinstra, Renée I. ; Dettmer, Katja ; Michels, Helen ; Farina, Francesca ; Krijnen, Jasper ; Melki, Ronald ; Buijsman, Rogier C. ; Ruiz Silva, Mariana ; Thijssen, Karen L. ; Kema, Ido P. ; Neri, Christian ; Oefner, Peter J. ; Nollen, Ellen A. A.

Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation

Article

van der Goot, Annemieke, Zhu, Wentao, Vázquez-Manrique, Rafael , Seinstra, Renée I., Dettmer, Katja , Michels, Helen, Farina, Francesca, Krijnen, Jasper, Melki, Ronald, Buijsman, Rogier C., Ruiz Silva, Mariana, Thijssen, Karen L., Kema, Ido P., Neri, Christian , Oefner, Peter J. and Nollen, Ellen A. A. (2012) Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation. Proceedings of the National Academy of Sciences of the United States of America 109 (37), pp. 14912-7.



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Details

Item typeArticle
Journal or Publication TitleProceedings of the National Academy of Sciences of the United States of America
PublisherNATL ACAD SCIENCES
Place of PublicationWASHINGTON
Volume109
Number of Issue or Book Chapter37
Page Rangepp. 14912-7
Date2012
Date of publication08 Aug 2014 08:53
InstitutionsMedicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number
ValueType
22927396PubMed ID
10.1073/pnas.1203083109DOI
Related URLs
URLURL Type
http://www.pnas.org/content/109/37/14912UNSPECIFIED
Classification
NotationType
Aging/physiologyMESH
Amyloid beta-Peptides/metabolismMESH
AnimalsMESH
Animals, Genetically ModifiedMESH
Caenorhabditis elegansMESH
Chromatography, LiquidMESH
Computational BiologyMESH
DNA Primers/geneticsMESH
Fertility/geneticsMESH
Homeostasis/physiologyMESH
ImmunoblottingMESH
Longevity/geneticsMESH
Peptides/metabolismMESH
RNA InterferenceMESH
Reverse Transcriptase Polymerase Chain ReactionMESH
Tandem Mass SpectrometryMESH
Tryptophan/metabolismMESH
Tryptophan Oxygenase/metabolismMESH
alpha-Synuclein/toxicityMESH
KeywordsHEAT-SHOCK-FACTOR; CAENORHABDITIS-ELEGANS; ALPHA-SYNUCLEIN; KYNURENINE 3-MONOOXYGENASE; IN-VITRO; DISEASE; PROTEOSTASIS; EXPRESSION; IDENTIFICATION; LONGEVITY; Huntington; longevity
Dewey Decimal Classification600 Technology > 610 Medical sciences Medicine
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
StatusPublished
RefereedYes, this version has been refereed
Created at the University of RegensburgPartially
Item ID30571

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