Go to content
UR Home

Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation

van der Goot, Annemieke, Zhu, Wentao, Vázquez-Manrique, Rafael, Seinstra, Renée I, Dettmer, Katja, Michels, Helen, Farina, Francesca, Krijnen, Jasper, Melki, Ronald, Buijsman, Rogier C, Ruiz Silva, Mariana, Thijssen, Karen L, Kema, Ido P, Neri, Christian, Oefner, Peter J. and Nollen, Ellen A A (2012) Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation. Proceedings of the National Academy of Sciences of the United States of America 109 (37), pp. 14912-7.

Full text not available from this repository.

at PubMed

at publisher (via DOI)


Abstract

Toxicity of aggregation-prone proteins is thought to play an important role in aging and age-related neurological diseases like Parkinson and Alzheimer's diseases. Here, we identify tryptophan 2,3-dioxygenase (tdo-2), the first enzyme in the kynurenine pathway of tryptophan degradation, as a metabolic regulator of age-related α-synuclein toxicity in a Caenorhabditis elegans model. Depletion of ...

plus


Export bibliographical data



Item type:Article
Date:September 2012
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
22927396PubMed ID
10.1073/pnas.1203083109DOI
Related URLs:
URLURL Type
http://www.pnas.org/content/109/37/14912UNSPECIFIED
Classification:
NotationType
Aging/physiologyMESH
Amyloid beta-Peptides/metabolismMESH
AnimalsMESH
Animals, Genetically ModifiedMESH
Caenorhabditis elegansMESH
Chromatography, LiquidMESH
Computational BiologyMESH
DNA Primers/geneticsMESH
Fertility/geneticsMESH
Homeostasis/physiologyMESH
ImmunoblottingMESH
Longevity/geneticsMESH
Peptides/metabolismMESH
RNA InterferenceMESH
Reverse Transcriptase Polymerase Chain ReactionMESH
Tandem Mass SpectrometryMESH
Tryptophan/metabolismMESH
Tryptophan Oxygenase/metabolismMESH
alpha-Synuclein/toxicityMESH
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30571
Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons