Limm, Katharina, Ott, Corinna, Wallner, Susanne, Mueller, Daniel W., Oefner, Peter J., Hellerbrand, Claus and Bosserhoff, Anja-Katrin (2013) Deregulation of protein methylation in melanoma. European journal of cancer 49 (6), pp. 1305-1313.
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Abstract
Loss of methylthioadenosine phosphorylase (MTAP) expression and a concomitant accumulation of 5'-methyl-thioadenosine (MTA) characterise several tumour entities including malignant melanoma. MTA affects cellular signalling, proliferation and migration not only of cancer but also surrounding cells including lymphocytes and stromal fibroblasts. The mode of action of MTA is still not known. ...
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| Item type: | Article | ||||||||||||||||||||||||||||||||||
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| Date: | April 2013 | ||||||||||||||||||||||||||||||||||
| Institutions: | Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner) Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Pathologie | ||||||||||||||||||||||||||||||||||
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| Keywords: | PRMT; Methylthioadenosine; Melanoma; MAPK/ERK signalling; Protein arginine methylation | ||||||||||||||||||||||||||||||||||
| Dewey Decimal Classification: | 500 Science > 500 Natural sciences & mathematics 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine | ||||||||||||||||||||||||||||||||||
| Status: | Published | ||||||||||||||||||||||||||||||||||
| Refereed: | Yes, this version has been refereed | ||||||||||||||||||||||||||||||||||
| Created at the University of Regensburg: | Partially | ||||||||||||||||||||||||||||||||||
| Item ID: | 30573 |
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