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Deregulation of protein methylation in melanoma

Limm, Katharina, Ott, Corinna, Wallner, Susanne, Mueller, Daniel W., Oefner, Peter J., Hellerbrand, Claus and Bosserhoff, Anja-Katrin (2013) Deregulation of protein methylation in melanoma. European journal of cancer 49 (6), pp. 1305-1313.

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Abstract

Loss of methylthioadenosine phosphorylase (MTAP) expression and a concomitant accumulation of 5'-methyl-thioadenosine (MTA) characterise several tumour entities including malignant melanoma. MTA affects cellular signalling, proliferation and migration not only of cancer but also surrounding cells including lymphocytes and stromal fibroblasts. The mode of action of MTA is still not known. ...

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Item type:Article
Date:April 2013
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Medicine > Lehrstuhl für Innere Medizin I
Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
23265702PubMed ID
10.1016/j.ejca.2012.11.026DOI
Classification:
NotationType
Arginine/metabolismMESH
Cell Line, TumorMESH
Deoxyadenosines/metabolismMESH
Extracellular Signal-Regulated MAP Kinases/metabolismMESH
Gene Expression Regulation, NeoplasticMESH
HumansMESH
ImmunoblottingMESH
ImmunohistochemistryMESH
Melanoma/pathologyMESH
MethylationMESH
Nuclear Proteins/metabolismMESH
Protein Processing, Post-TranslationalMESH
Protein-Arginine N-Methyltransferases/metabolismMESH
Purine-Nucleoside Phosphorylase/metabolismMESH
Reverse Transcriptase Polymerase Chain ReactionMESH
Thionucleosides/metabolismMESH
Keywords:PRMT; Methylthioadenosine; Melanoma; MAPK/ERK signalling; Protein arginine methylation
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30573
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