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Deregulation of protein methylation in melanoma

Limm, Katharina ; Ott, Corinna ; Wallner, Susanne ; Mueller, Daniel W. ; Oefner, Peter J. ; Hellerbrand, Claus ; Bosserhoff, Anja-Katrin



Abstract

Loss of methylthioadenosine phosphorylase (MTAP) expression and a concomitant accumulation of 5'-methyl-thioadenosine (MTA) characterise several tumour entities including malignant melanoma. MTA affects cellular signalling, proliferation and migration not only of cancer but also surrounding cells including lymphocytes and stromal fibroblasts. The mode of action of MTA is still not known. ...

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