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Bone marrow transplantation improves the outcome of Atm-deficient mice through the migration of ATM-competent cells

Pietzner, Julia, Baer, P. C., Duecker, R. P., Merscher, M. B., Satzger-Prodinger, C., Bechmann, I., Wietelmann, A., Del Turco, D., Doering, C., Kuci, S., Bader, P., Schirmer, Sophie, Zielen, S. and Schubert, R. (2013) Bone marrow transplantation improves the outcome of Atm-deficient mice through the migration of ATM-competent cells. Human molecular genetics 22 (3), pp. 493-507.

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Abstract

Ataxia telangiectasia (A-T) is a highly pleiotropic disorder. Patients suffer from progressive neurodegeneration, severe bronchial complications, immunodeficiency, hypersensitivity to radiotherapy and elevated risk of malignancies. Leukemia and lymphoma, along with lung failure, are the main causes of morbidity and mortality in A-T patients. At present, no effective therapy for A-T exists. One ...

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Item type:Article
Date:February 2013
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
23100326PubMed ID
10.1093/hmg/dds448DOI
Classification:
NotationType
AnimalsMESH
Ataxia Telangiectasia/therapyMESH
Ataxia Telangiectasia Mutated ProteinsMESH
Blood-Brain Barrier/metabolismMESH
Blotting, WesternMESH
Bone Marrow TransplantationMESH
CD4-Positive T-Lymphocytes/metabolismMESH
CD8-Positive T-Lymphocytes/metabolismMESH
Cell Cycle Proteins/metabolismMESH
Cell MovementMESH
ChimerismMESH
DNA-Binding Proteins/metabolismMESH
Disease Models, AnimalMESH
GenotypeMESH
Green Fluorescent Proteins/metabolismMESH
Lung/metabolismMESH
Magnetic Resonance ImagingMESH
MiceMESH
Mice, TransgenicMESH
Peripheral Blood Stem Cell TransplantationMESH
PhenotypeMESH
PhosphorylationMESH
Protein-Serine-Threonine Kinases/metabolismMESH
Spleen/metabolismMESH
Thymus Gland/metabolismMESH
Tumor Suppressor Proteins/metabolismMESH
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Item ID:30581
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