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Bone marrow transplantation improves the outcome of Atm-deficient mice through the migration of ATM-competent cells

Pietzner, Julia ; Baer, P. C. ; Duecker, R. P. ; Merscher, M. B. ; Satzger-Prodinger, C. ; Bechmann, I. ; Wietelmann, A. ; Del Turco, D. ; Doering, C. ; Kuci, S. ; Bader, P. ; Schirmer, Sophie ; Zielen, S. ; Schubert, R.



Abstract

Ataxia telangiectasia (A-T) is a highly pleiotropic disorder. Patients suffer from progressive neurodegeneration, severe bronchial complications, immunodeficiency, hypersensitivity to radiotherapy and elevated risk of malignancies. Leukemia and lymphoma, along with lung failure, are the main causes of morbidity and mortality in A-T patients. At present, no effective therapy for A-T exists. One ...

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