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NMR metabolomic analysis of dairy cows reveals milk glycerophosphocholine to phosphocholine ratio as prognostic biomarker for risk of ketosis

Klein, Matthias S., Buttchereit, Nina, Miemczyk, Sebastian P, Immervoll, Ann-Kathrin, Louis, Caridad, Wiedemann, Steffi, Junge, Wolfgang, Thaller, Georg, Oefner, Peter J. and Gronwald, Wolfram (2012) NMR metabolomic analysis of dairy cows reveals milk glycerophosphocholine to phosphocholine ratio as prognostic biomarker for risk of ketosis. Journal of proteome research 11 (2), pp. 1373-1381.

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Abstract

Ketosis is a common metabolic disease in dairy cows. Diagnostic markers for ketosis such as acetone and beta-hydroxybutyric acid (BHBA) are known, but disease prediction remains an unsolved challenge. Milk is a steadily available biofluid and routinely collected on a daily basis. This high availability makes milk superior to blood or urine samples for diagnostic purposes. In this contribution, we ...

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Item type:Article
Date:February 2012
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
22098372PubMed ID
10.1021/pr201017nDOI
Classification:
NotationType
AnimalsMESH
Biological Markers/metabolismMESH
CattleMESH
Cattle Diseases/metabolismMESH
FemaleMESH
Ketosis/veterinaryMESH
Metabolomics/methodsMESH
Milk/chemistryMESH
Nuclear Magnetic Resonance, Biomolecular/methodsMESH
Phosphatidylcholines/metabolismMESH
Phosphorylcholine/metabolismMESH
Reproducibility of ResultsMESH
Statistics, NonparametricMESH
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30590
Owner only: item control page
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