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T cells become licensed in the lung to enter the central nervous system

Odoardi, Francesca ; Sie, Christopher ; Streyl, Kristina ; Ulaganathan, Vijay K ; Schläger, Christian ; Lodygin, Dmitri ; Heckelsmiller, Klaus ; Nietfeld, Wilfried ; Ellwart, Joachim ; Klinkert, Wolfgang E F ; Lottaz, Claudio ; Nosov, Mikhail ; Brinkmann, Volker ; Spang, Rainer ; Lehrach, Hans ; Vingron, Martin ; Wekerle, Hartmut ; Flügel-Koch, Cassandra ; Flügel, Alexander



Abstract

The blood–brain barrier (BBB) and the environment of the central nervous system (CNS) guard the nervous tissue from peripheral immune cells. In the autoimmune disease multiple sclerosis, myelin-reactive T-cell blasts are thought to transgress the BBB and create a pro-inflammatory environment in the CNS, thereby making possible a second autoimmune attack that starts from the leptomeningeal vessels ...

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