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T cells become licensed in the lung to enter the central nervous system

Odoardi, Francesca, Sie, Christopher, Streyl, Kristina, Ulaganathan, Vijay K, Schläger, Christian, Lodygin, Dmitri, Heckelsmiller, Klaus, Nietfeld, Wilfried, Ellwart, Joachim, Klinkert, Wolfgang E F, Lottaz, Claudio, Nosov, Mikhail, Brinkmann, Volker, Spang, Rainer, Lehrach, Hans, Vingron, Martin, Wekerle, Hartmut, Flügel-Koch, Cassandra and Flügel, Alexander (2012) T cells become licensed in the lung to enter the central nervous system. Nature 488 (7413), pp. 675-679.

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Abstract

The blood–brain barrier (BBB) and the environment of the central nervous system (CNS) guard the nervous tissue from peripheral immune cells. In the autoimmune disease multiple sclerosis, myelin-reactive T-cell blasts are thought to transgress the BBB and create a pro-inflammatory environment in the CNS, thereby making possible a second autoimmune attack that starts from the leptomeningeal vessels ...

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Item type:Article
Date:August 2012
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identification Number:
ValueType
22932379PubMed ID
10.1038/nature11337DOI
Classification:
NotationType
Adoptive TransferMESH
AnimalsMESH
Autoimmunity/immunologyMESH
Blood-Brain Barrier/immunologyMESH
Brain/pathologyMESH
Cell Adhesion Molecules, Neuronal/metabolismMESH
Cell MovementMESH
Cerebrovascular CirculationMESH
Disease Models, AnimalMESH
Encephalomyelitis, Autoimmune, Experimental/pathologyMESH
Gene Expression ProfilingMESH
Immunologic MemoryMESH
Lung/pathologyMESH
Lymphocyte ActivationMESH
Myelin Sheath/immunologyMESH
Nerve Growth Factors/metabolismMESH
RatsMESH
Rats, Inbred LewMESH
T-Lymphocytes/pathologyMESH
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30594
Owner only: item control page
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